Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
نویسندگان
چکیده
منابع مشابه
Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients.
PURPOSE Vismodegib, an orally bioavailable small-molecule Smoothened inhibitor, is approved for treatment of advanced basal cell carcinoma (BCC). We conducted a pharmacokinetic study of vismodegib in patients with advanced solid tumors to explore the effects of food on drug exposure. EXPERIMENTAL DESIGN In part I, patients were randomized to fasting overnight (FO), a high fat meal (HF), or a ...
متن کاملCancer Therapy: Clinical Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
Purpose: Vismodegib, an orally bioavailable small-molecule Smoothened inhibitor, is approved for treatment of advancedbasal cell carcinoma (BCC).We conducted apharmacokinetic study of vismodegib in patients with advanced solid tumors to explore the effects of food on drug exposure. Experimental Design: In part I, patients were randomized to fasting overnight (FO), a high fat meal (HF), or a low...
متن کاملthe effect of creative writing instruction on lexical density of advanced efl learners writing
چکیده ندارد.
15 صفحه اولthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2013
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-3829